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Promising Biological Mechanisms for Slowing Age-Related Change
How Web3 and Biotechnology Are Transforming Health Data Management?
Top Biotech and Life Sciences Trends to Watch in 2025
Seсrets of Longevity: Biologiсal Meсhanisms Behind Slowing Down Aging
Top Chemistry Tools Every Student Should Know
The Role of Chemistry in Sustainable Agriculture

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Activating gene transcription

According to the scientists’ idea, the luciferase in the transcription factor quickly uses the substrate provided to it, and as soon as it ends, the transcription factor stops activating gene transcription.

To test how well the factor they created meets expectations, the researchers measured the expression level of the protein they controlled over time.

According to the results of measurements, 4-6 hours after the addition of furimazine, the level of protein synthesis reached a maximum, and then sharply decreased.

About fluorescent protein

The researchers then tested the system in vivo in animal models. The livers of mice were transfected with plasmids in which the expression of a reporter fluorescent protein was controlled by an engineered chimeric transcription factor.

After the administration of furimazine to mice, the expression of the reporter protein also reached a maximum after four hours and decreased sharply afterwards.

The amplitude of the expression level changed with the concentration of the administered furimazine. In addition, protein expression could be re-“turned on” at intervals of eight hours.

Glucose level in the cell-implanted mice

Cells in which insulin production was controlled by a chimeric transcription factor were encapsulated in a semipermeable membrane.

The membrane permeable only to low molecular weight compounds (<72 kilodaltons) protects foreign cells from physical contact with the immune system of the host animal. Type 1 diabetic mice were given five milligrams of furimazine per kilogram of animal weight and blood glucose was measured after three hours.

The glucose level in the cell-implanted mice decreased compared to the rest (non-implanted, furimazine-free mice).