Custom Synthesis Lab
Chemir’s custom synthesis lab is used for all types of organic reactions on scales from milligrams to kilograms. Much of the custom synthesis work done is the synthesis of analytical standards and pharmaceutical intermediates, in addition to process development.
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The laboratory has ample hood space, including two walk-in hoods for larger-scale process equipment. Balances range from micro balances for accurately weighing less than 1 mg of material to large multi-kg balances for larger reactions and equipment. Drying ovens and vacuum ovens are used to dry glassware for anhydrous reactions and to remove water and residual solvents from products. All types of organic reactions can be conducted under an inert atmosphere using high precision temperature controllers. Reactions can be run at high pressures in the Parr® autoclaves. Products can be purified to high purity with our preparative chromatography systems, including reverse phase and normal phase chromatography (using up to 5 kg of silica gel). The lyophilizers and banks of rotary evaporators aid in the isolation of purified products. Products can also be purified by distillation using the Kugelrohr stills, traditional columns, and high vacuum pumps.
Chemir’s broad array of analytical laboratory capabilities, including NMR, LCMS and GC, allow for the efficient monitoring of reactions and the characterization of final products.
